AS 602801 ( AS602801; PGL-5001; PGL 5001; Bentamapimod )

产品货号. M17611 CAS No. 848344-36-5

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

AS 602801
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

AS 602801(Bentamapimod) is a novel, orally active inhibitor of JNK.
产品描述

Bentamapimod, also known as AS602801 and PGL5001, is a JNK Inhibitor. AS602801 induces regression of endometriotic lesions in animal models. AS602801 interrupts immune pathways. Bentamapimod induced regression of endometriotic lesions in endometriosis rodent animal models without suppressing ER action. Endometriosis is an estrogen (ER)-dependent gynecological disease caused by the growth of endometrial tissue at extrauterine sites.
同义词

AS602801; PGL-5001; PGL 5001; Bentamapimod
通路

Others
靶点

Other Targets
受体

JNK1; JNK2; JNK3
研究领域

Inflammation/Immunology
适应症

——

CAS Number

848344-36-5
分子量

457.55
分子式

C25H23N5O2S
纯度

98%
溶解度

DMSO : 14.29 mg/mL. 31.23 mM;
SMILES

N#CC(c1nc2ccccc2s1)c1nc(OCc2ccc(CN3CCOCC3)cc2)ncc1
化学全称

2-(1,3-benzothiazol-2-yl)-2-[2-({4-[(morpholin-4-yl)methyl]phenyl}methoxy)pyrimidin-4-yl]acetonitrile

1. Ferrandi C, et al. Mult Scler. 2011 Jan;17(1):43-56.

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